abstract：BACKGROUND:P2X7 receptor (P2X7R), trigger of acute inflammatory responses via the NLRP3 inflammasome, is hyperfunctioning in patients with Sjögren's syndrome (SS), where it stimulates IL-18 production. Some patients with SS develop a mucosa-associated lymphoid tissue non-Hodgkin's lymphoma (MALT-NHL). OBJECTIVES:To pr...

journal_title：Journal of internal medicine

authors： Baldini C,Santini E,Rossi C,Donati V,Solini A

更新日期：2017-08-01 00:00:00

abstract：:A major challenge in the growing field of bioelectronic medicine is the development of tissue interface technologies promoting device integration with biological tissues. Materials based on organic bioelectronics show great promise due to a unique combination of electronic and ionic conductivity properties. In this re...

journal_title：Journal of internal medicine

authors： Löffler S,Melican K,Nilsson KPR,Richter-Dahlfors A

更新日期：2017-07-01 00:00:00

abstract：:The human nervous system is a vast network carrying not only sensory and movement information, but also information to and from our organs, intimately linking it to our overall health. Scientists and engineers have been working for decades to tap into this network and 'crack the neural code' by decoding neural signals...

journal_title：Journal of internal medicine

authors： Bouton C

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The impact of season when determining a serum 25-hydroxyvitamin D (S-25OHD) cut-off level for optimal bone health is unknown. OBJECTIVE:To investigate the relative importance of S-25OHD for bone mineral density (BMD) by season. METHODS:A subcohort of 5002 Swedish women (mean age 68 years), randomly selecte...

journal_title：Journal of internal medicine

authors： Michaëlsson K,Wolk A,Byberg L,Mitchell A,Mallmin H,Melhus H

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:IgA nephropathy (IgAN) is a common complex disease with a strong genetic involvement. We aimed to identify novel, rare, highly penetrant risk variants combining family-based linkage analysis with whole-exome sequencing (WES). METHODS:Linkage analysis of 16 kindreds of South Italian ancestry was performed us...

journal_title：Journal of internal medicine

authors： Cox SN,Pesce F,El-Sayed Moustafa JS,Sallustio F,Serino G,Kkoufou C,Giampetruzzi A,Ancona N,Falchi M,Schena FP,European IgAN Consortium.

更新日期：2017-02-01 00:00:00

abstract：AIM:There is firm evidence of a relation between type 2 diabetes (T2DM) and increased risks of cancer at various sites, but it is still unclear how different antihyperglycaemic therapies modify site-specific cancer risks. The aim of this study was to provide a complete characterization of all possible associations betw...

journal_title：Journal of internal medicine

authors： Kautzky-Willer A,Thurner S,Klimek P

更新日期：2017-02-01 00:00:00

abstract：:Neuroendocrine tumour of the small intestine (SI-NET), formerly known as midgut carcinoid tumour, is the most common small intestinal malignancy. The incidence is rising, with recent reports of 0.67 per 100 000 in the USA and 1.12 per 100 000 in Sweden. SI-NETs often present a challenge in terms of diagnosis and treat...

journal_title：Journal of internal medicine

authors： Stålberg P,Westin G,Thirlwell C

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Studies have shown that lipoprotein(a) [Lp(a)], an important carrier of oxidized phospholipids, is causally related to calcific aortic valve stenosis (CAVS). Recently, we found that Lp(a) mediates the development of CAVS through autotaxin (ATX). OBJECTIVE:To determine the predictive value of circulating ATX...

journal_title：Journal of internal medicine

authors： Nsaibia MJ,Mahmut A,Boulanger MC,Arsenault BJ,Bouchareb R,Simard S,Witztum JL,Clavel MA,Pibarot P,Bossé Y,Tsimikas S,Mathieu P

更新日期：2016-11-01 00:00:00

abstract：:The success of antiretroviral therapy in treating HIV infection has greatly prolonged life expectancy in affected individuals, transforming the disease into a chronic condition. A number of HIV-associated non-AIDS comorbidities have emerged in the ageing HIV-infected population, including osteoporosis and increased ri...

journal_title：Journal of internal medicine

authors： Compston J

更新日期：2016-10-01 00:00:00

abstract：:The introduction of targeted biological therapies has revolutionised the management of immune-mediated inflammatory diseases (IMIDs) such as rheumatoid arthritis, ankylosing spondylitis, psoriasis and inflammatory bowel disease. Following treatment with these therapies, many patients experience significant improvement...

journal_title：Journal of internal medicine

authors： Isaacs JD,Cutolo M,Keystone EC,Park W,Braun J

更新日期：2016-01-01 00:00:00

abstract：:Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'om...

journal_title：Journal of internal medicine

authors： Bergström G,Berglund G,Blomberg A,Brandberg J,Engström G,Engvall J,Eriksson M,de Faire U,Flinck A,Hansson MG,Hedblad B,Hjelmgren O,Janson C,Jernberg T,Johnsson Å,Johansson L,Lind L,Löfdahl CG,Melander O,Östgren CJ,

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Patients with psoriasis have an increased risk of type 2 diabetes. The gastrointestinal system plays a major role in normal glucose metabolism, and in healthy individuals, postprandial insulin secretion is largely mediated by the gut incretin hormones. This potentiation is termed the incretin effect and is r...

journal_title：Journal of internal medicine

authors： Gyldenløve M,Vilsbøll T,Zachariae C,Holst JJ,Knop FK,Skov L

更新日期：2015-12-01 00:00:00

abstract：:Ebola virus disease (EVD) is a zoonotic disease that causes severe haemorrhagic fever, with high fatality rates of up to 90% in humans. Today, there is no effective treatment available. Person-to-person transmission occurs through exposure to blood or body fluids, which can threaten other household members and first-l...

journal_title：Journal of internal medicine

authors： Mirazimi A

更新日期：2015-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are one of a growing class of noncoding RNAs that are involved in the regulation of a wide range of metabolic processes including cellular differentiation, cell proliferation and apoptosis. The generation of miRNA is regulated in complex ways, for example by small interfering RNAs (small nucleolar a...

journal_title：Journal of internal medicine

authors： Nolte-'t Hoen EN,Van Rooij E,Bushell M,Zhang CY,Dashwood RH,James WP,Harris C,Baltimore D

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Addition of assessment of comorbid diseases ('D') and oxygen saturation ('S') to the CRB-65 score has been recommended to improve its accuracy for risk stratification in community-acquired pneumonia (CAP). The aim of this study was to validate the resulting DS-CRB-65 score in a large cohort of patients with ...

journal_title：Journal of internal medicine

authors： Kolditz M,Ewig S,Schütte H,Suttorp N,Welte T,Rohde G,CAPNETZ study group.

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:It has been hypothesized that epicardial adipose tissue (EAT) exerts pathogenic effects on cardiac structures. We analysed the associations between EAT and both cardiovascular (CV) disease risk factors and CV events in patients with chronic kidney disease (CKD). PATIENTS AND METHODS:We included 277 nondialy...

journal_title：Journal of internal medicine

authors： Cordeiro AC,Amparo FC,Oliveira MA,Amodeo C,Smanio P,Pinto IM,Lindholm B,Stenvinkel P,Carrero JJ

更新日期：2015-07-01 00:00:00

abstract：:Personalized medicine involves the selection of the safest and most effective pharmacological treatment based on the molecular characteristics of the patient. In the case of anticancer drugs, tumour cell alterations can have a great impact on drug activity and, in fact, most biomarkers predicting response originate fr...

journal_title：Journal of internal medicine

authors： Rodríguez-Antona C,Taron M

更新日期：2015-02-01 00:00:00

abstract：:Epilepsy affects 50 million persons worldwide, a third of whom continue to experience debilitating seizures despite optimum anti-epileptic drug (AED) treatment. Twelve-month remission from seizures is less likely in female patients, individuals aged 11-36 years and those with neurological insults and shorter time betw...

journal_title：Journal of internal medicine

authors： Walker LE,Mirza N,Yip VLM,Marson AG,Pirmohamed M

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In the past two decades, an increasing number of nationwide, Swedish Healthcare Quality Registries (QRs) focusing on specific disorders have been initiated, mostly by physicians. Here, we describe the purpose, organization, variables, coverage and completeness of 103 Swedish QRs. METHODS:From...

journal_title：Journal of internal medicine

authors： Emilsson L,Lindahl B,Köster M,Lambe M,Ludvigsson JF

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Hypovitaminosis D, a condition that is highly prevalent in older adults aged 65 years and above, is associated with brain changes and dementia. Given the rapidly accumulating and complex contribution of the literature in the field of vitamin D and cognition, clear guidance is needed for researchers and clini...

journal_title：Journal of internal medicine

authors： Annweiler C,Dursun E,Féron F,Gezen-Ak D,Kalueff AV,Littlejohns T,Llewellyn DJ,Millet P,Scott T,Tucker KL,Yilmazer S,Beauchet O

更新日期：2015-01-01 00:00:00

abstract：:Atherosclerosis is a silent chronic vascular pathology that is the cause of the majority of cardiovascular ischaemic events. The evolution of vascular disease involves a combination of endothelial dysfunction, extensive lipid deposition in the intima, exacerbated innate and adaptive immune responses, proliferation of ...

journal_title：Journal of internal medicine

authors： Badimon L,Vilahur G

更新日期：2014-12-01 00:00:00

abstract：:Cardiovascular disease remains the most prevalent cause of human morbidity and mortality in ageing Western societies. Basic and translational scientific efforts have focused on the development and improvement of diagnostic and therapeutic strategies to limit the burden of associated diseases, such as stroke and myocar...

journal_title：Journal of internal medicine

authors： Maegdefessel L

更新日期：2014-12-01 00:00:00

abstract：:Alpha-1 antitrypsin (AAT) deficiency is an under-recognized hereditary disorder associated with the premature onset of chronic obstructive pulmonary disease, liver cirrhosis in children and adults, and less frequently, relapsing panniculitis, systemic vasculitis and other inflammatory, autoimmune and neoplastic diseas...

journal_title：Journal of internal medicine

authors： de Serres F,Blanco I

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:Algorithms to predict the future long-term risk of patients with stable coronary artery disease (CAD) are rare. The VIenna and Ludwigshafen CAD (VILCAD) risk score was one of the first scores specifically tailored for this clinically important patient population. The aim of this study was to refine risk predi...

journal_title：Journal of internal medicine

authors： Kleber ME,Goliasch G,Grammer TB,Pilz S,Tomaschitz A,Silbernagel G,Maurer G,März W,Niessner A

更新日期：2014-08-01 00:00:00

abstract：:Orthopaedic implants are highly susceptible to infection. The aims of treatment of infection associated with internal fixation devices are fracture consolidation and prevention of chronic osteomyelitis. Complete biofilm eradication is not the primary goal, as remaining adherent microorganisms can be removed with the d...

journal_title：Journal of internal medicine

authors： Zimmerli W

更新日期：2014-08-01 00:00:00

abstract：:The socio-economic impact of Alzheimer's disease (AD) and other dementias is enormous, and the potential economic challenges ahead are clear given the projected future numbers of individuals with these conditions. Because of the high prevalence and cost of dementia, it is very important to assess any intervention from...

journal_title：Journal of internal medicine

authors： Wimo A,Ballard C,Brayne C,Gauthier S,Handels R,Jones RW,Jonsson L,Khachaturian AS,Kramberger M

更新日期：2014-03-01 00:00:00

abstract：:Primary adrenal insufficiency (PAI), or Addison's disease, is a rare, potentially deadly, but treatable disease. Most cases of PAI are caused by autoimmune destruction of the adrenal cortex. Consequently, patients with PAI are at higher risk of developing other autoimmune diseases. The diagnosis of PAI is often delaye...

journal_title：Journal of internal medicine

authors： Husebye ES,Allolio B,Arlt W,Badenhoop K,Bensing S,Betterle C,Falorni A,Gan EH,Hulting AL,Kasperlik-Zaluska A,Kämpe O,Løvås K,Meyer G,Pearce SH

更新日期：2014-02-01 00:00:00

abstract：:Autoantibodies against three different postsynaptic antigens and one presynaptic antigen at the neuromuscular junction are known to cause myasthenic syndromes. The mechanisms by which these antibodies cause muscle weakness vary from antigenic modulation and complement-mediated membrane damage to inhibition of endogeno...

journal_title：Journal of internal medicine

authors： Huijbers MG,Lipka AF,Plomp JJ,Niks EH,van der Maarel SM,Verschuuren JJ

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Red blood cell distribution width (RDW), a measure of variation in erythrocyte volume, has been associated with several cardiovascular disorders, but the relationship with atrial fibrillation (AF) remains unclear. We investigated the association between RDW and incidence of first hospitalization due to AF in...

journal_title：Journal of internal medicine

authors： Adamsson Eryd S,Borné Y,Melander O,Persson M,Smith JG,Hedblad B,Engström G

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Atherosclerosis is an inflammatory disease of the arterial wall that leads to myocardial infarction and stroke. Regulatory T cells (Tregs) and IL-10 exert significant anti-atherogenic effects in experimental models of atherosclerosis by modulating vascular inflammation. We have previously shown that Mycobact...

journal_title：Journal of internal medicine

authors： Ovchinnikova OA,Berge N,Kang C,Urien C,Ketelhuth DF,Pottier J,Drouet L,Hansson GK,Marchal G,Bäck M,Schwartz-Cornil I,Lagranderie M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Metabolomics is a versatile unbiased method to search for biomarkers of human disease. In particular, one approach in cancer therapy is to promote apoptosis in tumour cells; this could be improved with specific biomarkers of apoptosis for monitoring treatment. We recently observed specific metabolic patterns...

journal_title：Journal of internal medicine

authors： Halama A,Riesen N,Möller G,Hrabě de Angelis M,Adamski J

更新日期：2013-11-01 00:00:00

abstract：:Developing new pharmacotherapies for autism spectrum disorder (ASD) is a challenge. ASD has a complex genetic architecture, several neurobiological phenotypes and multiple symptom domains. However, new opportunities are emerging that could lead to the development of 'targeted' and individualized pharmacological interv...

journal_title：Journal of internal medicine

authors： Ecker C,Spooren W,Murphy D

更新日期：2013-10-01 00:00:00

abstract：:In healthy individuals, insulin resistance is associated with physiological conditions such as pregnancy or body weight gain and triggers an increase in beta cell number and insulin secretion capacity to preserve normoglycaemia. Failure of this beta cell compensation capacity is a fundamental cause of diabetic hypergl...

journal_title：Journal of internal medicine

authors： Thorens B

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Findings from animal studies indicate that growth hormone (GH) may stimulate the production of the putative metabolic regulator fibroblast growth factor 21 (FGF21). We investigated whether circulating FGF21 levels are altered in patients with GH deficiency and characterized how levels of this growth factor ar...

journal_title：Journal of internal medicine

authors： Lundberg J,Höybye C,Krusenstjerna-Hafstrøm T,Bina HA,Kharitonenkov A,Angelin B,Rudling M

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Excess body weight and a sedentary lifestyle are associated with the development of several diseases, including cardiovascular disease, diabetes and cancer in women. One proposed mechanism linking obesity to chronic diseases is an alteration in adipose-derived adiponectin and leptin levels. We investigated t...

journal_title：Journal of internal medicine

authors： Abbenhardt C,McTiernan A,Alfano CM,Wener MH,Campbell KL,Duggan C,Foster-Schubert KE,Kong A,Toriola AT,Potter JD,Mason C,Xiao L,Blackburn GL,Bain C,Ulrich CM

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Inflammation is involved in the pathogenesis of cardiovascular disease and cognitive decline. Interleukin-6 (IL-6) has a role in cardiovascular disease, but the association of IL-6 concentration and the functional IL-6 -174 polymorphism with cognitive decline has not been demonstrated unequivocally. The obje...

journal_title：Journal of internal medicine

authors： Mooijaart SP,Sattar N,Trompet S,Lucke J,Stott DJ,Ford I,Jukema JW,Westendorp RG,de Craen AJ,PROSPER Study Group.

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:Combinations of inhaled corticosteroids (ICSs) and long-acting β2 -agonists (LABAs) are recommended for patients with moderate and severe chronic obstructive pulmonary disease (COPD). However, it is not known whether different fixed combinations are equally effective. The aim of this study was to investigate...

journal_title：Journal of internal medicine

authors： Larsson K,Janson C,Lisspers K,Jørgensen L,Stratelis G,Telg G,Ställberg B,Johansson G

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:A significant proportion of patients with chronic fatigue syndrome (CFS) also have postural orthostatic tachycardia syndrome (POTS). We aimed to characterize these patients and differentiate them from CFS patients without POTS in terms of clinical and autonomic features. METHODS:A total of 179 patients with...

journal_title：Journal of internal medicine

authors： Lewis I,Pairman J,Spickett G,Newton JL

更新日期：2013-05-01 00:00:00

abstract：:Many people infected with the human immunodeficiency virus type-1 (HIV) exhibit mild or severe neurological problems, termed HIV-associated neurocognitive disorder (HAND), even when receiving antiretroviral therapy. Thus, novel adjunctive therapies must be developed to overcome the neurotoxic effect of HIV. New therap...

journal_title：Journal of internal medicine

authors： Avdoshina V,Bachis A,Mocchetti I

更新日期：2013-05-01 00:00:00

abstract：:Orthostatic hypotension (OH) is a relatively common heterogenous and multifactorial disorder, traditionally classified as neurogenic (less common but often more severe) or nonneurogenic (more common, with no direct signs of autonomic nervous system disease). The different clinical variants of orthostatic intolerance i...

journal_title：Journal of internal medicine

authors： Fedorowski A,Melander O

更新日期：2013-04-01 00:00:00